OBMODTEA 2020: An Insight to Bio-Ceramics

OBMODTEA 2020: An Insight to Bio-Ceramics

The Department of Ceramic Engineering, NIT Rourkela, hosted a webinar series on Opportunities in Bioceramic Materials in Orthopaedic, Dental and Tissue Engineering Applications (OBMODTEA 2020) from 25th-29th September 2020. The 5-day long webinar consisted of a series of interactive sessions by some of the most renowned researchers in material science across India. The webinar offered a unique opportunity to acquire comprehensive knowledge and strengthen skills in current state-of-art research in the field of application of modern bioceramic materials.

With Prof. Animesh Biswas, Director, NIT Rourkela as the patron, and Prof. Debasish Sarkar as the Chairman, the event was organised successfully and received an overwhelming response. Each day witnessed two sessions. The 1st session was from 10:00 AM onwards, and the 2nd session started at 11:15 AM.

Day 1

25th of September marked the official commencement of the event. The inauguration ceremony of webinar witnessed the presence of Prof. S. K. Patel (Chief Guest), Prof. Debasish Sarkar (Chairman for the event and the HoD, Department of Ceramic Engineering, NIT Rourkela), Prof. Sudip Dasgupta (Convener), Prof. S.K Pratihar(Faculty Advisor, InCerS NIT Rourkela chapter), a representative from InCerS NIT Rourkela chapter.

OBMODTEA 2020, unfolded at about 10 AM. Prof. S.K. Patel did the inauguration of the event, who presided as the Chief Guest.

Following this, Prof. Debasish Sarkar, Chairman for the event and the Head of Department of Ceramic Engineering, said a few words. The event was then declared open.

Session-1

Prof. Sudip Dasgupta welcomed the guest speaker for the first session, Prof. Santanu Dhar, Professor at IIT Kharagpur. The session witnessed an enlightening lecture and insightful presentation by Prof. Santanu Dhara. He gave an extensive view on “Design, Development and Validation of Customized Implants using ethically Sourced Material”. He talked chiefly about:

  • Digitisation of medical problem
  • Ethically sourced materials
  • Customising manufacturing solution
  • Validation- In vitro and in vivo models.

Following the highly informative presentation, Prof. Dhara answered all the queries of the participants and the convenor.

Session-2

The second session of Day 1 was on the subject of “Piezoelectric Bioceramics as next-generation prosthetic orthopaedic implants” by Prof. Asutosh Dubey, Assistant Professor, IIT BHU. The presentation gave a comprehensive picture of:

  • Increasing the rate of healing of fractured bones and implants
  • Electrical activities in the body
  • Use of piezoelectricity in the treatment of cancer
  • Property enhancement of various piezoelectric and related materials.

There was a short discussion session at the end where Prof. Dubey clarified the doubts of the participants.

Day 2

Session-1

Prof. Sampath Kumar (Professor at Department of Metallurgical and Materials Engineering, IIT Madras), lectured about CaP Carriers, Cement and Composites. The presentation provided a widespread vision of:

  • Calcium Phosphate ceramics
  • NANO HA Morphology
  • Endodontology
  • Multifunctional nano-platform
  • CDHA based tetracycline drug delivery systems
  • Drug release from apatite nanoparticles
  • Cell attachment and proliferation study.

Prof. Kumar then cleared all the queries of the participants, following the lecture.

Session-2

The 2nd session witnessed an incisive lecture on “Development of ceramic materials for framework and layering of dental implants” by Prof. Parag Bhargava, Professor at Department of Metallurgical Engineering and Materials Science, IIT Bombay. A few topics which he discussed were:

  • Dental implants
  • Various parts of teeth and their distinct property
  • Materials used for the framework of dental crowns like lanthanum glass infiltrate alumina, alumina/zirconia monolith.

The session ended with the doubt clearing round, where Prof. Parag Bhargava answered all the queries.

Day 3

The third day started with Prof. Dasgupta introducing the speakers of the day and subsequently handing over the platform.

Session-1

The session started at 10 am with Prof. Kantesh Balani, from IIT Kanpur, enlightening the student community with his vast knowledge and expertise on “Adhesion of Bacteria on Various Bio-surfaces”. He spoke on a wide range of topics such as:

  • Biomaterials and associated bacterial infections
  • Development of anti-bacterial biomaterial
  • Staphylococcus aureus, Stainless Steel, Ti-6Al-4v, and hydroxyapatite
  • Atomic Force Microscopy
  • Effect of Ag and ZnO reinforcement on adhesion force

Prof. Balani provided a great deal of knowledge on preparation of bacterial AFM probes, techniques to measure the adhesion force, joint replacement. He even mentioned the importance of Biomaterial devices in usage of orthopaedic, bone cement, cardiovascular, and vascular fields.

The session ended after Prof. Balani cleared all the doubts and answered a few questions which came from the students’ end.

Session-2

The second session for the day started at around 11:30 am with Dr Samit Kumar Nandi, from WBUAFS Kolkata, emphasising on “In vivo bone regeneration of doped bio-ceramics and glasses”. He enlightened the students with a very detailed and precise description on metallic ion doping, in vivo characterisation parameters, and grafting. He mentioned various types of testing and studies, such as:

  • Fluorochrome labelling study
  • Angiography
  • Transmission electron microscopy
  • Densitometry
  • Biomechanical testing
  • Scanning Electron Microscopic Study
  • Intravital fluorescence video microscopy

Dr Nandi explained the usage of trace elements as dopants and their role in the overall performance of bone. Adding to that, he provided a proper explanation to why we graft by mentioning osteogenesis, osteoinduction, osteoconduction, and structural, mechanical support. The session ended with a question-answer session where Dr Nandi cleared all the doubts of the students.

Day 4

Session-1

The first session was taken over by Dr Jui Chakraborty, from CGCRI Kolkata, in which she substantiated a great deal of information on “The cutting edge applications of nano/meso glass in healthcare”. A few topics from her session are:

  • Antibacterial study of B-Ag-BAG vs antibiotics
  • Peripheral Neuropathy and Diabetic Ulcer
  • Bone augmentation materials
  • Bioactivity of glass and its importance

Dr Chakraborty elaborated on a large domain of topics related to her session. She emphasised the drawbacks of current market available dressings, value-added antibacterial, radiopaque bioactive glass-based injectable bone augmentation material, etc. Dr Chakraborty also explained about hard tissue generation, problems with bioinert ABCs, and elaborated a lot of details about Vertebroplasty and Kyphoplasty. The session was very enlightening for the students as the topics discussed were elaborated in reasonable detail, and the speaker solved all the doubts with proper explanation.

Session-2

The second session for the day was taken over by Dr Piyali Basak from Jadavpur University, Kolkata. Dr Basak instructed the students on “Approaches to prevent Implant Infection”. She focused on implant failure, implant infection details, implant infection prevention. Concerning the significant area of discussion on Implant infection prevention, Dr Basak emphasised on all the information related to that topic. A few includes:

  • Strategies for infection prevention
  • Biofilm prevention, identification, and treatment
  • Work done to prevent implant infection
  • Management summary

Apart from this, she also focused on bioceramics, which are a class of ceramics used for repair and replacement of diseased and damaged parts of the organ, as a biomaterial. Dr Basak also mentioned about the current biofilm-related research, which included Surface modification, antimicrobial PDT, Biosensors for early detection, and theranostic nanoparticles, to name a few. She ended her session by explaining about biocompatibility and its verification. Her session was a very interactive one. She clarified all the doubts from the students’ side and marked the end of Day 4.

Day 5

Session-1

The curtains to the final day were pulled by Dr Sirshendu Shekhar Ray, enlightening the student community with his vast knowledge on the topic of Biomolecular glass: A new class of material for Medical Applications. Prof. Ray is from the Department of Biotechnology and Biomedical Engineering at NIT Rourkela. Starting with a brief description of what bioglass is about, he went to its further applications and development in different fields of engineering. Developed by Larry L. Hench in late 60', Bioglass is specifically composed of silica, calcium oxide, sodium oxide and phosphorus pentoxide. It has several applications in the domains of

  • Bone regeneration
  • Dental adhesives
  • Implant dentistry
  • Air abrasion

Further, he touched different aspects of opportunities in bioceramic materials in orthopaedic, dental and tissue culture. Prof. Ray explained in detail about which all Biomolecules constitute the bioglass and how the material is being formed.

Next up was the topic of hemocompatibility analysed through a graph of percentage hemolysis vs absorbance followed by a brief idea of in vitro calcification.

Summing up, he concluded touching the point stating

  • It's the first time synthesised glass from Biomolecules.
  • The glass produced is transparent, amorphous and contains vitreous phosphate networks.
  • Biomolecular glass contain heterogeneously distributed nanomoids

Session-2

The final session was taken up by Prof. Debrupa Lahiri, from the department of biomaterials and multiscale mechanics lab, Department of Metallurgical and Materials Engineering at IIT Roorkee. The session was about surface-modified metallic orthopaedic Implant for sustained drug release.

She started with the topic of orthopaedic implants and the consequences of infections. So, to serve safety for a more extended period without any rejection, a metallic Implant offers

  • Excellent bio-compatibility (non-toxic)
  • High corrosion resistance
  • Suitable mechanical properties
  • High wear resistance
  • Osseo-integration

Bio-ceramics provides several applications such as

  • Bone-scaffold and bone-filler
  • Implant coating
  • Drug delivery system

In orthopaedics, HA bone filler has taken a significant leap in bone grafting surgery and treatment of large bone defects. Total hip arthroplasty, total knee arthroplasty and ankle arthroplasty serve the central domain of biomaterials for orthopaedics.

Summing up, she concluded stating several highlighted facts such as

  • Surface modification with porous HA coating
  • Antibacterial efficacy and osteoconductivity attained simultaneously
  • Surface modification of Implant with gradient HA.

Closing Ceremony

No doubt, the event OMBODTEA 2020, i.e. Opportunities of Bioceramic Materials in Orthopedic, Dental and Tissue Engineering and Applications. The Department of Ceramic Engineering as well as the executive body of InCerS NIT Rourkela student chapter not only did provide an online platform but also managed the smooth conduction of the webinar. The esteemed speakers of the event, Prof. Santanu Dhara from IIT Kharagpur, Dr Ashutosh Kumar Dubey from IIT BHU, Prof. T. S. Sampath Kumar from IIT Madras, Prof. Parag Bhangava from IIT Bombay, Prof. Kantesh Balani from IIT Kanpur, Dr Samit K. Nandu from WBUAFS Kolkata, Dr Jai Chakraborty from CGCD Kolkata, Dr Piyali Basak from Jadavpur University, Dr S. S. Ray from NIT Rourkela and Prof. Debrupa Lahiri from IIT Roorkee. The goal to explore the insights of advanced synthesis and processing for bioceramic materials to find solutions for emerging challenges in orthopaedic, dental and tissue engineering applications was being achieved. The knowledge imparted by them to the budding inquisitive minds makes them perceive a lot, thereby building a desire in them to take the technology ahead in several applications and do welfare to the society.

Team MM reached out to one of the coordinator of the event and the President of NITR-ICS, Ekta Kumari, for knowing about her stance on the implementation of Obmodtea.

It all started when one of the mentors of our chapter proposed us to include the InCerS chapter in this webinar for a better reach and platform. And with the support of the convenor of the event Prof Sudip Dasgupta, HoD of Ceramic Engineering Prof. Debasish Sarkar, and the Faculty advisor of our InCerS chapter Prof. S K Pratihar, we were able to implement it properly."

Webinars and online sessions have become way too familiar these days pertaining to the problems faced due to the pandemic. Even in online sessions and webinars, a lot of planning and management has to be done to ensure that the event is being conducted smoothly without much of connectivity issues. This is what Ekta Kumari had to say,

Management- A captain or leader is as good as his/her team. I am extremely thankful to the executive body of the 20-21 session for showing so much dedication and professionalism towards this chapter. As I am busy with my research intern in tata steel, the core team took the whole responsibility to manage and coordinate the works among themselves. In a brief period, we managed to contact more than ten colleges across India, and around 200+ participants registered for the webinar. As demanded by some speakers the broadcasting was kept private, so the team took the responsibility of sending the mail of webinar link to each and everyone (200 participants nearly )at least 12 hours before the event for consecutive five days. And at the same time, we tried to respond to every query of participants through mail and call from our side.

Team MM appreciates ICS and Department of Ceramic Engineering for making Obmodtea happen and ensure that the event is carried on smoothly.

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